Thursday, April 30, 2015

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Wednesday, April 29, 2015

There are those who argue that there is a lack of sunlight that is the problem but the body


This week I thought to write about the season depression, known as seasonal affective disorder or SAD. What is it then? As the name suggests, it is depression or anxiety aortic aneurysm related to the vicissitudes of the seasons. Many believe that this is only happening aortic aneurysm when we go from summer to winter, but it is not unusual to feel this even when the winter becomes spring. But now we are focusing on the most common; the one that is related to how much sunlight we get in the fall.
Thought it might be a good idea to write about sad before aortic aneurysm the setting of the clock and start thinking now. I can start with myself. Here you go and suck the sunshine as much as you can. Body and soul love to be with a little extra vitamin D. Yes, last week, yes. This week, I would not do anything other than eat and sleep. And it's the same thing every year, I always forget, and every year about this time I get to me that my world will perish.
How do you then recognize the symptoms of SAD? The most common symptoms are just like any other depression, sadness and hopelessness and more but you often get an increased need for sleep and larger appetites, feel cravings for carbohydrates aortic aneurysm (Vårguiden; in 2011, the NHS; 2012). So in other words you may not only lazy you want to stay all day in bed or lying on the couch, eating chips and must watch Home to the farm.
What are the different types of treatments? aortic aneurysm Yes, the Swedish model seems to print antidepressant medication. Medically increases the body's access to seratonin; the substance that makes us feel good. It is really necessary? Many would argue the opposite. A common alternative is to phototherapy. When the days get shorter and darker increase the body's production of melatonin, the substance in the body that makes us tired. In other words, less sunlight leads to more fatigue. aortic aneurysm Phototherapy simply means that you are sitting in front of a special light that simulates natural sunlight between 20-60 minutes a day to reduce the levels of melatonin and boosting the body's natural levels of seratonin. Lumie is the only Swedish company that specializes in these lamps what I can find, and they are quite expensive. One option might be to buy one from ebay or amazon. If you are lucky to live in Umeå, you can even get it for free in certain bus shelters (SVT, 2012) Some may feel that this option takes a lot of time. You can also get help through therapy, then usually with cognitive behavioral therapy where you learn to rule out negative aortic aneurysm thinking.
There are also health food such as St. John's wort that will work well. Just be aware that St. John's wort may interact with other medicines such as birth control aortic aneurysm pills, discuss this with your doctor first. The best advice seems to be to be outdoors as much as you can possibly can. It is said that only a ten-minute walk every day, even if it is overcast just as good if not better than any of the methods mentioned earlier.
There are those who argue that there is a lack of sunlight that is the problem but the body's conversion from light to dark. So my personal advice is to give you in the fall, pick nice yellow leaves in shades and take them out. Self I become very calm of yellow. So who knows maybe there are several aortic aneurysm reasons why we call mushrooms of the forest and autumn gold!
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Tuesday, April 28, 2015

I do not like winter, I hate the darkness that present themselves and believe myself that I suffer


I do not like winter, I hate the darkness that present themselves and believe myself that I suffer from SAD (Seasonal Affective Disorder). std symptoms Last year it was terribly, I've never gone into such a depression that I did then during Christmas. std symptoms I was obsessed with incredibly dark thoughts, slept away the whole Christmas and maddening piss. It was at its worst in December and January, but was not quite good Forens std symptoms spring came when everything became std symptoms much brighter. I've been thinking the last few weeks known by some symptoms again and have therefore decided to buy a light bulb with artficiellt sunlight. I hope it will help! Therefore, it should also be very nice to me not to go back to Sweden and celebrate Christmas this year because it even darker there than in England. Can not dispute the same for me which lamp I want to buy, however, is there anyone of you have any experience? A strong, good lamp or a 'Sun Rise' lamp with a combined alarm clock?
I have been a wake-up light from Philip, and I lööööv it! It is an alarm clock, but, one can have the spark of a standard bulb too. Do not know whether the "help" in the way you want, the thing with this is that it primarily to help a waking better, std symptoms and provide a more energy during the day. Sure, I do not know how much it actually helps and what is just psychological, but I can still say that it helps me. And that's the important thing! In contrast, I'll never be like that deeply influenced by the weather, I have just very difficult for mornings. And I hate usual beep-beep-beep alarm clocks. I know quite a big difference when I use it here, that I wake up in a more comfortable way, and feel more rested. It works so that the light comes on gradually over a half hour before you want to wake up, so the body will have time to prepare, type. Then you can choose std symptoms if you want the audio to, which I need. Chirping birds, lapping waves, grodkväk, radio and (terrible terrible) beeps, the signals available on the I have! So, I really like it, but I think it depends on what it is you need! 25 October 2009 at 14:22
Sadly, lightboxes and even väckarklckorna definitely works. std symptoms If you can afford it, I recommend that you obtain both (the light in alarm clocks are not sharp enough to be used as lightbox). If you can not afford both so you get to think about what time of day is the hardest. Do you have problems to get up so the alarm can be the solution. Is your problem blues and apathy so buy a lightbox, it must have at least 10,000 std symptoms lux to work well. Have had a lightbox since last year and really notice a difference. But when it's hardest I take even using a solarium, a maximum of 2 times per year, however, because I neither are after sunburn std symptoms or cancer, and St. John's Wort tablets from Holland & Barrett. 26 October 2009 at 20:01
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Autumn and winter depression or SAD is a natural but unusual strong reaction to the dark season. No


Autumn and winter depression or SAD is a natural but unusual strong reaction to the dark season. Nothing feels great and it's hard to concentrate. The cause of SAD is that our eyes are not exposed to enough light during these seasons tretinoin cream but the lack of light need not be the only cause. - From Vårdguiden
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Monday, April 27, 2015

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Sad is the English term for recurrent winter depression. There is no similar description in Swedish, which corresponds quite well with the National Board's position that the phenomenon does not deserve attention or treatment. The English name "Seasonal Affective Disorder" describes ovulation quite well that depression is linked with the season.
When the daylight gets shorter and paler during the winter months affects the whole of nature. Trees lose their leaves, migratory birds fleeing southward, flowers wither away, hedgehogs, and bears hibernate. But how are we affected people? Many feel a little tired after the November darkness falls, it becomes more difficult to get up in the morning and there is less energy in the evening. ovulation The lack of daylight contributes to a chemical imbalance ovulation in the brain hypothalamus. Some people seem to be more sensitive than others to these changes, and suffer from SAD.
If you suffer from SAD are affected ovulation every aspect of life in a negative way during the dark winter months. Things that one usually finds enjoyable becomes uninteresting. It has no energy to socialize with friends and family, will withdraw rather undan.Trots that men tired all the time becomes your sleep disturbed and fragmented. Manvaknar too early or oversleep significantly. You just want to sleep anytime during the day. A sense avständig "jet lag" comes. Kroppsklockanhamnari of step, and then it becomes even hunger disturbed.
Claustrophobia, confusion, hopelessness and pessimism color tanks. Sex drive is reduced, one can become easily irritated and get anxiety about how to perform everyday activities of daily life. Many suffer ovulation from feelings of guilt and shame over how they feel. SAD is a disease that can have extremely serious consequences if the victim does not help, then it can lead in its most extreme manifestation of suicide.
About 10% of the population in Finland is estimated to suffer from SAD, and it should be a similar proportion in Sweden, when both countries located at the same latitude. Sadly received their official name of Dr. Norman Rosenthal in 1984. He has done the most extensive research on the disease and the light of important significance for the treatment of SAD.
General Nature Odd
There's something really pretty about nature reclaiming the ITS domain once we are gone. We had this wonderful piece of concept art we underdeveloped really early on, and there are all of These wild animals thathave escaped from a zoo, ...
By UN Women ambassador ovulation Emma Watson's acclaimed speech about feminism and the importance of male involvement in gender equality, the campaign "HE She" had a major impact worldwide. "He for She" aims to highlight the ...
Larry Stylinson - Is a name for the romance between Louis Tomlinson and Harry Styles from One Direction. ovulation One Direction was in the X-Factor in 2010 where they finished third. The name came from the beginning when several fans noticed that Louis and Harry was closer than the other guys. (Liam, Niall and Zayn) First it was a 'bromance' names, because they were just really close friends but then it started some of the fans notice that there was more beneath the surface. And then split the fandom into two parts those who saw their love and those who believed the lies. Larry shippers we are called to see, believe and support their love. Harry Styles ovulation is connected with Louis Tomlinson and Louis Tomlinson, along with Harry Styles.
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Sunday, April 26, 2015

The tour goes by the name


The tour goes by the name "Surf John Stevens Christmas Sing-A-Long: Seasonal Affective Disorder Yuletide Disaster Pageant on Ice". We dare not speculate too much what this means, other than to Surf John sounds like a right Cool, relaxed name as any kind of Real Estate berries.
Sufjans upcoming US trip comes in the wake of the announcement of his new julbox tension headaches - Silver & Gold: Songs For Christmas, Volumes tension headaches 6-10 - which is a sequel to the previous collection that was released in 2006. Silver & Gold contains materials from just 2006 and four years.


Friday, April 24, 2015

Because swallowing is painful, eat blended vegetable soup made with Onions and garlic, Which have a


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This is an inflammation of the tonsils, Which is DUE to acute urinary. body mass index The tonsils are lymph nodes on either side of the back of the mouth, and Their function is to protect Against Upper Respiratory Tract infections, Ta'if They Become infected, inflamed and swollen They get with fluids and white blood cells, body mass index making swallowing painful and eating difficult . The main symptoms presented can be a sore throat, swollen and / or coated tonsils, difficulty swallowing, swollen lymph nodes in the neck, possible fever, Headache and earache, and breath may smell unpleasant, among others. Many people body mass index practice natural remedies to treat tonsillitis and throat infections without even, Realizing it. The traditional Remedy is a soothing Drink of hot water mixed with honey and freshly squeezed lemon juice.
Because swallowing is painful, eat blended vegetable soup made with Onions and garlic, Which have antiseptic qualities, Cabbage, bell peppers, broccoli body mass index and tomatoes, Which are good sources of vitamin C, and carrots and sweet Potatoes for beta-carotene content.
Alternatively, gargle with raspberry leaf tea or add a teaspoonful of Chopped fresh sage leaves to a cup of BOILING water, then cover and STEEP for 10 minutes, strain, and use as a gargle when cool.
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Prolonging medicine and to broaden the penis. . Its price is 330 US dollars (330 US Dollars) ...
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a.)Internal monistat lymph nodes these are found in the body cavities or deep in the muscles,the major once are popleteal lymphnodes,which monistat is found in  between semitendinous and biceps femoris monistat mesenteric lymph nodes, found in the mesentery hepatic lymphnodes,found monistat in the hilus of the liver splenic lymph nodes,deans of spleen left and right bronchial lymphnodes,found at bifurcation of the trachea into left and right bronchi mediasternal lymph nodes,found along the trachea and oesophagus b.)External/superficial lymphnodes mandibular lymph node,usually are two in nuclear one on each side they are found at the angle of the mandible between sternocephalicus muscles monistat and the ventral part of the mandibular salivary gland. parotid lymphnode,found below the root of the ears lying on the posterior part of the masseter muscle and partially covered by the dorsally end of the parotid salivary gland. prescapula lymphnodes,found at the anterior border of the scapula above the sholder joint. prefemoral/precrural lymphnodes,found along the stifle joint on the aponeurosis of the obliquus abdominis externus superficial inguinal lymphnodes,this differ in two sexes *in bull they are situated below the prepubic tendon and in narrow interfemoral space.*in cow they are situated above the posterior border monistat of the base of the mammary glands.
Our online college (V.O Institute) page your required to register yourself if you don't have an account,if you have you can log in and select the class you want to take....The instructors in VETERINARY ONLINE INSTITUTE felt that their students need some additional training in veterinary, but the students had such a heavy load of required courses that they could include several VETERINARY courses.From this was evolved the idea that, after taking class here, students monistat be required to take actual practice in those classes on the field practice .
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Thursday, April 23, 2015

Tumor arising out suddenly and you have the pain is often caused by injury water retention of the b


Tumor or technical language, swollen lymph nodes or glands, swelling of the glands are emerging in a person's body after body injury and attacked by bacteria or bacterial infections or wavurugao wasababishao normal functioning of the body.
These glands (lymph nodes / glands) are available various parts of the body, and his work is to discover and attack specific items or various insects that enter the body and cause disease, water retention so it is very important in the defense or immune system. Among the parts of the body where these glands are found are the areas of the hips (groin), behind the ears, under the jaw and chin, back of the head, armpits sites (armpit) and neck. Often the things water retention that cause someone water retention might tumor include someone getting water retention infections eg leishmaniasis throat or tonsillitis, but away from the infection also one can be kaumia body parts eg foot mine ulcer, although getting bubonic NOT must be sore, man also can get the tumor from the elements of the immune system not being in good condition, eg if someone has a disease such as disease the joint of the fingers and toes, Rheumatoid Arthritis, or if the person has immune deficiency syndrome, AIDS, can get bubonic , with it possible for a person with blood disorders, blood cancer, leukemia, also can get the tumor.
Tumor symptoms include pain thyroid section, eg it could be armpits, in the hips or neck, one can get the flu, the relevant parts can be red (this is due to increased blood flow in that area). Under normal water retention conditions it is difficult to keep part of the body and sensing glands, water retention this is due to its small size, it has the shape of a grain of bean and its size is not to exceed one inch. If one mine or mine kaumia infection or anything that could make thyroid ivimbe, that person will be able to keep the relevant sections and to be able to feel it in your body's glands.
Tumor arising out suddenly and you have the pain is often caused by injury water retention of the body or body parts get certain infections eg sore throats, tonsillitis. Depending on the patient's history or someone with this tumor, the doctor will recommend certain types of tests done in order to give the light of what treatment you receive. There are some, as I mentioned earlier that the source is possible, so it is the transmission of microorganisms eg bacteria, so the doctor will make a decision which group of drugs (antibiotics) be appropriate depending on your situation, there are also others water retention who are tumors that did not have pain and possibly its size is increasing day to-day, this is also possible, so it is something water retention else and after enough tests appropriate care can be provided.
Dear reader, this article I wrote to share with you ideas about what you knew about the tumor, and not an alternative to making you reaching health professional if you have a problem, come to the experts who are around you in order to know how best to help you.
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Wednesday, April 22, 2015

what is a pedophile? an elderly man who usually seasonal affective disorder stare at little girls a


what is a pedophile? an elderly man who usually stare at little girls and trying to make contact with the girls to sexualt advantage seasonal affective disorder of young girls is a pedophile, when you see an elderly man who watch a lot of little girls and surfing through the mobile, Internet chat sites ä
what is a pedophile? an elderly man who usually seasonal affective disorder stare at little girls and trying to make contact with the girls to sexualt advantage of young girls is a pedophile, when you see an elderly man who watch a lot of little girls and surfing through the mobile, Internet chat sites is a pedophile To you who are adult Pedophilia is a dicey topic that we might try to avoid. But the topic is important. It is about our children and their safety, their future. The right to be children and avoid becoming victims of adult sexuality. This website is created to help children learn more about the subject, to help them avoid and deal with this ghastly. Pedophiles seasonal affective disorder collaborates, children must have someone to collaborate with. We can not just do things of children's head, but we must give them the support and knowledge. Scientific knowledge about pedefoli does not seem complete without consist of a lot of guesses and assumptions that are not always fully-founded. There are studies that generated what we might call the statistical material but very little about the actual mechanisms. Therefore, we need more research, more knowledge. At the same time, one should seasonal affective disorder not believe that there are easy answers. The causes of pedophilia and how the forms it takes are very different so one can almost certainly say that there is not one but many different answers. This website's facts are based on private investigations of what pedophiles themselves have expressed in different contexts and tasks we have received from various seasonal affective disorder sources. The UN has set the boundary between childhood and adulthood at age 18, younger is classed as children and older adults. But the border is not natural in terms of pedophilia. seasonal affective disorder On the one hand, many parents attest that they still regard their 20-year-old children who are just children. But the major objective boundary between förpubertet and puberty. All sexual offenses must be fought, regardless of age. However, we need different startegier for different ages. Pedophiles organize themselves, although perhaps the majority really disorganized. Some know it has enough recent years become a little more difficult then the police also internationally begun to hunt pedophiles on limestone. The Internet has been what the catalyst is for the car - but in the wrong direction. One should also not ignore the fact that there are pedophiles who also series uses scientific studies as they read as hell reads the Bible, and all Sköns arguments. Paedophiles who deny what this is about and distorts objectivity. You might not be surprised - that pedophiles are trying to defend themselves and who they are. One can sometimes read about pedophiles who try to justify pedofeli with "scientific arguments" and others who try to belittle the injuries kids can take from this. Let us not be fooled by them. Not least, it is important that those who are about to commit these crimes understand that they harm the child and that there are just a few exceptions to the rule. We have to get them to abstain - not justify what they want to do. Are we in some sense to correct this requires a lot of us. We must organize ourselves. We must protect the children. We need research so our knowledge is increased - but do not believe that we get simple answers but see increased knowledge as a step to find suggestions on how the problem can be minimized. We must find strategies that not only about police action. Almost all children are naive in the beginning. Many children live a life where they yearn to be confirmed by adults. Combiner it with pedophiles who "comes from all directions" and try to find ways to achieve their goals. We need to give children knowledge - making them less naive. Not to mention the "dirty old men" because a pedophile might look like anyway, seasonal affective disorder without describing the threat faces. We must work to ensure that children receive the adult contacts they need but without pedophiles. We need to plug the holes from where pedophiles. Getting pedophiles to understand seasonal affective disorder that it is always wrong and remove their myths about motsattsen, and to get them to refrain seasonal affective disorder entirely from becoming seasonal affective disorder active pedophiles are certainly necessary. For slightly seasonal affective disorder older children, you should have a law prohibiting group sex with a person under 18. Today, perpetrators often free when it comes victims over 15 because this law is lacking. Otherwise we have some laws we need although the issue of the lack of the organizations working with children should learn about people suspected of crimes against children, and so on. Support our work, support all the other organizations that are working to stop pedophiles. But remember that pedophiles may seek to infiltrate everywhere. We shall not give the last word to pedophiles. Support us. Learn more about pedophiles in English. Back to Home 50 girls may have sexutnyttjats capture fucking pedophiles 2 A large number of children may have been sexually abused after having had

Tuesday, April 21, 2015

Do not forget the social democratic local politician who last year was sentenced for throwing a cha


Oh well. Then came the next case where an SD politician caught grossly racist comments, this time the chairman of the SD Stockholm. Am I surprised? No. I have now lost count of all the Sweden Democrats caught in racist activities of various kinds. Is not it just as well to SD recognize the right of that is a racist party instead of holding on and play the hypocrite with his so-called "zero tolerance"? Probably would not affect their election results. Nor would it affect their ability to gain power in parliament, then the other parties still did not want to cooperate with them.
This happens in all parties, but it is only the Sweden Democrats as old media highlights. When you heard the media talk about, for example ?: http://www.friatider.se/c-politiker-spred-kritik-mot-judar-fr-kandidera-nd http://avpixlat.info/2014/06/23/ blogger-in-racially-bleed / http://www.bt.se/nyheter/mufare-far-ga-efter-hitlerhalsning(3039972).gm Reply Delete
Not to mention all doomed and odömda leftists who practice and advocate violence as a political method, despite the party leader's half-hearted scleroderma rejection. scleroderma But he is hypocritical course on how flådigt scleroderma he lives and his predecessors put her daughter in private school, although he was against them, so no one gets surprised over the double standards ... Reply Delete
Do not forget the social democratic local politician who last year was sentenced for throwing a chair at another woman at a sports bar. Later threatened social democrat the abused woman with "I'll bury you alive" in a threatening text messages. http://m.gp.se/nyheter/val2014/val/1.2481015-andra-lokala-politiker-som-akt-fast Reply Delete
Would perhaps be appropriate to consider the difference between the concepts of racism scleroderma and racial discrimination, and the concept of race and its place in politics and society. Do doctors guilty of racism / discrimination because they suspect thalassemia in Mellanösternhärstammande but not in others? Can we allow the division of people into races / ethnic groups in some purposes but not others: should it be OK to have labels that hate crime for whites who beat brown but not too brown abusive white, or brown abusive brown? Should not be allowed at all to check ethnicity / race / whatever of the perpetrators? Should we have different requirements for school children scleroderma of the same ethnic background? ETC. We run liberal policies in the truest sense, scleroderma we no problem scleroderma with this (maybe with another though). But it is not likely to happen for a while, so we shall see that bone out above properly. Reply Delete
Sure, ok, there is atleast partially a racist party. Is probably an over-representation of stale opinions when compared to the Swedish people in general. But for us ordinary WARE-SLAVE who have not done bostadskariär, can look forward to an old age in Spain or on the Riviera after the villa is sold. We are dependent on a functioning welfare, scleroderma humane and compassionate senior care. We who do not want to see 48miljarder / 4y.o. go to the immigration office. scleroderma We who do not want to see our neighborhoods taken over by criminal gangs made up of people with virtually 100% of asylum immigrant background. We who do not want to see our children's schools and teaching decay beyond recognition scleroderma on the basis of messy and even clean criminal pupils, unfortunately, back then, consideration of asylum immigrant background. scleroderma We who want to see properly palpable and dissuasive penalties, and for criminals who relapse into crime real life sentence to get them away from the streets. scleroderma We who do not sit in an air-conditioned office and feel the goodness grow within us as what we invested in the stock market. We wonder why 85- 90% of those who seek asylum in January not show valid identification documents, what hides them? They'll probably all around from, even from countries in Europe. We who think that the person who paid taxes during their working life in Sweden goes before someone from another country, no matter how pity it is about the latter. We who is damned tired of dialogue policemen, brandhenar and the eternal nagging about gays and lesbians. We who have these opinions, which is also completely normal scleroderma in the rest of the world. We think it weighs quite easy when someone gets portrayed in a gossip magazine for referring to a study showing that Arabs are violent by nature, believes, however, get buy that argument. Or that someone says that Gypsies are criminals, the latter is additionally true. Ask any police officer. They Gypsies who have an honest living and not criminals or grants supplied are easily counted. And then you have to hear drivel about the racist scleroderma structures, they only structures that have contributed to Roma exclusion is their own. If they were known as hard-working and blameless citizens would be well companies queue to employ them, rent cars when you know that the car will return full tank and washed well would not be a problem. Anyway. What is the alternative !?

Monday, April 20, 2015

77% of Sweden


Afdelingslæge / overlege Rheumatology, Kong Christian X's Gigthospital, Denmark. Spec doctors, Närhälsan Bjurslätt Medical Center, Gothenburg. Resident physicians, clinics in Blekinge, Lideta Healthcare, Sweden, New York. Spec physicians, family medicine, Kungsport doctors, District Hospital, Gothenburg. Spec physician / resident physicians, family medicine, Närhälsan Ljungskile medical center, Uddevalla. Spec physicians, family medicine, family physicians at the Square, laholm. Doctors and specialists, Centric, Sweden. Spec doctor (LUS), neurology with stroke direction, Östersund melancholia trailer Hospital, Östersund. Spec doctor (LUS), cardiology, Östersund Hospital, Östersund. Spec doctor (LUS), hematology, Östersund Hospital, Östersund. Spec doctor (LUS), gastroenterology / hepatology, Östersund Hospital, Östersund. Spec doctor / consultant, rehabilitation medicine, Östersund Rehab Center, Ostersund.
77% of Sweden's doctor reads Läkartidningen, melancholia trailer which is by far the highest of the target group. Whether you are launching a new product or recruit a doctor so we can help you find the media mix that best suits your needs. Read more
Läkartidningen ADDRESS: Läkartidningen, PO Box 5603, 114 86 Stockholm Tel: 08-790 33 00 E-mail: webmaster@lakartidningen.se melancholia trailer CHIEF EDITOR AND PUBLISHER: Pär Gunnarsson melancholia trailer INVOICE ADDRESS: Läkartidningen Publishing Co., FE515, PLF1020, 105 69 Stockholm

Glucose-6-phosphate dehydrogenase deficiency is the most common congenital enzymdefekten in humans


Figure 1. Glucose-6-phosphate dehydrogenase (G6PD) shin splints catalyzes the reaction in which glucose-6-phosphate (G6P) is oxidized to 6-phosphogluconolactone (6PG). At the same time the NADP is converted to NADPH which in turn can reduce oxidized glutathione shin splints (GSSG) to its reduced form (GSH). GSH is required for the reduction of hydrogen peroxide (H 2 O 2) during oxidative stress.
Figure 3. Blodmorfologisk analysis showed the presence of so-called bite cell (1), sfärocyter (2) and Pappenheimer-cells (3), as seen in hemolysis due to oxidative stress in patients with G6PD deficiency.
Glucose-6-phosphate dehydrogenase deficiency is the most common congenital enzymdefekten in humans and can cause episodes of hemolytic anemia induced by external factors, such as certain drugs, shin splints ingestion of fava beans or other serious illness.
Lack of glucose-6-phosphate dehydrogenase (G6PD) is the most common shin splints congenital enzymdefekten in humans and is found in about 400 million people worldwide [1]. The incidence is higher in malaria endemic areas, especially in Africa, the Middle East and South Asia, suggesting that G6PD deficiency is likely to appear protective against malaria shin splints [2].
More than 140 different mutations of the enzyme deficiency has been identified, most of which are point mutations. The gene is X-linked, so G6PD deficiency is common in men [3]. G6PD enzyme catalyzes the first and rate limiting step in the hexose monophosphate shunt (HMP shunt), i.e. the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous formation of NADPH from NADP (Figure 1). NADPH is among other things important for the body's defenses against shin splints free radicals during oxidative stress. Red blood cells are particularly dependent on G6PD enzyme which is the only one that provides them with NADPH [3]. Factors that may cause oxidative stress and thereby hemolytic anemia in individuals with G6PD deficiency is recognized in Fact 1. Varying symtobild
Favism, ie hemolysis after ingestion of fava beans (fava beans) (Figure 2), has been known since more than 2000 years. Already Pythagoras should have forbidden his followers to eat fava beans. All types of G6PD deficiency shin splints does not give rise to favism [4].
G6PD found in all body cells, but the clinical consequences of G6PD deficiency becomes largest in the erythrocytes, where the HMP shunt is the only way to produce shin splints NADPH as they lack mitochondria [3]. G6PD deficiency severity varies depending on the enzyme activity remaining. The clinical picture varies from asymptomatic to chronic hemolysis, and onset may be early in the form of neonatal jaundice.
Symptoms include anemia shin splints nonspecific symptoms such as fatigue shin splints and dizziness, and jaundice and back pain. In the blood chemical analyzes seen an image in hemolytic anemia. The diagnosis is made by measuring the activity of the enzyme in the blood. G6PD deficiency affects in most cases not life expectancy [3]. There is no specific treatment for G6PD deficiency. Patients are advised to avoid the factors that can trigger hemolysis. If necessary, if symtomgivnade anemia occurs, blood transfusions are given [5]. Case
The case concerns a 46 year old man who sought emergency department at Karolinska University Hospital Huddinge because of suspected blood in the urine then two days and fatigue, and diffuse abdominal pain since about a week. Previously, shin splints he was essentially healthy, in addition to episodes of abdominal pain of unknown cause since childhood. He took no medications regularly. He was originally from Morocco and mostly Arabic speaking. shin splints Accompanying partner helped to interpret the emergency department.
Upon arrival, he was pale, tired, afebrile, takypnoisk shin splints and icteric. Oxygen saturation was 87 percent with 10 liters of oxygen to the mask. The heart auskulterades with regular rhythm shin splints with a frequency shin splints of 93 beats / minute. The abdomen was generally shin splints palpationsöm. ECG was normal. Laboratory tests showed: CRP 88 mg / L, glucose 6.3 mmol / l, creatinine 124 ĩmol / l, the electrolyte otherwise normal. A blood count was Hb 96 g / dl, MCV 107 fL, TPK 181 10 9 / L and WBC 18.3 10 9 / L. Liver samples showed shin splints bilirubin 93 ĩmol / L, AST 1.93 μkat / L, ALT 0.44 μkat / L, ALP 1.0 μkat / L and pancreatic 0.13 μkat / L. D-dimer was 2.6 mg / l. Blood gas with 10 l of oxygen showed shin splints pH 7.51, p CO 2 4.9 kPa, P 2 O 34.5 kPa and base excess 6 mmol / l. CT of the thorax and abdomen were ordered but showed no pulmonary embolism and nothing abnormal in the abdomen. Some emfysematösa bullae and less bronchiectasis was noted (patient was a smoker).
The patient was traded in the emergency department of the surgeon's shelter, whose preliminary assessment was unclear abdominal pain with hematuria. The differential diagnoses considered was schistosomiasis (snail fever), another parasite infection shin splints and viral hepatitis. The patient was admitted fasting on surgical emergency department with intravenous fluids and pain relief when needed and received hematurikateter with spoldropp. Hb fell during the night of 84 g / l, and the patient is transfused was therefore with two units packed red blood cells. The next morning Hb 96 g / l. The patient shin splints was taken over as a medical patient after consultation with medi

Sunday, April 19, 2015

77% of Sweden


Afdelingslæge / overlege Rheumatology, Kong Christian X's Gigthospital, Denmark. Spec doctors, Närhälsan dapoxetine Bjurslätt Medical Center, Gothenburg. Resident physicians, clinics in Blekinge, Lideta Healthcare, dapoxetine Sweden, New York. Spec physicians, family medicine, Kungsport doctors, District Hospital, dapoxetine Gothenburg. Spec physician / resident physicians, family dapoxetine medicine, Närhälsan Ljungskile dapoxetine medical center, Uddevalla. Spec physicians, family medicine, family physicians at the Square, laholm. Spec physicians, family medicine, dapoxetine medical center Närhälsan Lerum, Lerum. Doctors and specialists, Centric, Sweden. Spec doctor (LUS), neurology with stroke direction, Östersund Hospital, dapoxetine Östersund. Spec doctor (LUS), cardiology, Östersund Hospital, Östersund. dapoxetine Spec doctor (LUS), hematology, Östersund Hospital, Östersund. Spec doctor (LUS), gastroenterology / hepatology, Östersund Hospital, Östersund. Spec doctor / consultant, rehabilitation medicine, Östersund Rehab Center, Ostersund.
77% of Sweden's doctor reads Läkartidningen, which is by far the highest of the target group. Whether you are launching a new product or recruit a doctor so we can help you find the media mix that best suits your needs. Read more
Läkartidningen ADDRESS: Läkartidningen, PO Box 5603, 114 86 Stockholm Tel: 08-790 33 00 E-mail: webmaster@lakartidningen.se CHIEF EDITOR AND PUBLISHER: Pär Gunnarsson INVOICE ADDRESS: Läkartidningen Publishing Co., FE515, PLF1020, 105 69 Stockholm

Saturday, April 18, 2015

2013 (122) July (3) June (9) May (15) April (17) March (24) February (28) January (


... Check my new stylish pin I wear to work clothes: Well, blood is really my thing and thesis work rolls on the train. I am doing a work on the blood disease thalassemia stress symptoms and analyzes the two enzymes linked to the disease. Tomorrow is the time for half-time control and a smaller presentation will be harvested. Wish me luck! A good luck may also be needed tonight when it will Ljusrusas.
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Yep, today I am a little yttepytte little proud of myself. A tad like that. * Nods * I had a note that was a little tricky to diagnosis coding. Patienen had a symptom and therefore had undergone a test, a test which it then straight was no code. After a couple vändors googling I came up with a suggestion of how I would do. And can you imagine - my colleague bought my proposal. Yeeey, it feels so awesome that I get ANYTHING at times, even without having read the course. :)
In addition, I have eaten most of the day, it feels like. Mini-APT with Unveiling of summer employees. I got an oil lamp (which I cut myself when I unpacked it, but fiiin is the * nods *) and a flower. rheumatoid arthritis Not what I expected, but an incredibly nice gesture. Then we ate lunch and afternoon tea was discovered a sandwich cake in the fridge. Food Day today. * Nods *
Berit Brynja Says: August 13th, 2009 at. 22:07
But oh, now I became Impad! Coolers, boolers! By the way, have you found icd.nu ... ?? Love it when doctors say "And so, enter the code for cristapunktion" or "And so, he had thalassemia .... but it .... I do not remember the code for ... But you can find !! ".... !! :-D
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Friday, April 17, 2015

2011 (644) July (347) June (183) April (3) March (48) News: Disease and tragedies behind


The new reception for children in AngeredGteborgs-PostenDen first dagsjukvrdsenheten at Angered hospital was opened IGR and it is a unit for chronically ill children with the rare disease thalassemia, a disease that innebr blood transfusion with TV three weeks apart. Today the business is run on. All about Personal Assistance Personal assistance. more Had the person can not afford to bear the cost of a personal assistant got him completely rely on family gerd symptoms members or friends could help him with everyday tasks.
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2011 (644) July (347) June (183) April (3) March (48) News: Disease and tragedies behind djurfrbud Blogged: Henderson gerd symptoms remained in the hospital - D & auml; en & auml; rt: Genetic testing creates ondig concern - ... Senate re: Teir about the disease that role play. - D & auml; s: New reception for children Angered - D & auml; en & auml; rt: Abbott genomfr CALM Study - New: New bolndsk Film Festival in Dalsbruk - If the PA Bicycle Accident in roundabout - NEW: Disease and tragedies behind djurfrbud If the PA Krnkraftchefen to hospital - D & auml; s: Norrbotten values as are required to be centralized? ... L & auml; s: Hospitals missed cancers - Fri sharp INFO: That Mr. r Huntington's disease - Senate again: doctors GRT of confidentiality - NEWS: 19-rig UF fretagare knner itself blst About: Vasafrjan hjlps out of the ice - Sweden's D & auml; en & auml; RT: press, gerd symptoms radio o television rvlkomna ... News: 40 vessels awaiting p assistance - NOW: hospitals for the hndiga - today's gerd symptoms New: doctor GRT of professional secrecy - If PA : mental gerd symptoms patient spoken fr threat to doctors NEW: Why not municipally? - Norrkpings D & auml; s: SPA week with beskp Kuressaare News on: Expensive to grow older in the bay - rnskldsviks News on: tricked by "hemtjnst" - Helsingborgs News on: Perstorp's gives no to the refugee children in NEW: Valmjlighet in the future hemtjnst - News: Faith, hope and love - Vsterbottens NEWS: County Council special gerd symptoms review on Blog New: Japan: Television workers to hospital after ... L & auml; p : Money for drogfrebyggande - Northern New: Japan: Television workers to hospital gerd symptoms after D & auml; en & auml; rt: Lagfrslag about genetic testing - Swedish ... Blog New: Ddliga hierarchies - Today's News: Big ladugrdsbrand in Skne - News: Vasafrjan hjlps out of the ice - Sweden's news: Kerns go-ahead - NEWS: Larsson on private VRD p Congress - News: the first case of ddlig Disease - New: Upplands V SBY took stdet from Ida, 8 - NEWS: doctor GRT of professional secrecy - D & auml; s: Women taking birth itself hemtjnst-stlder - About: A medical care limping - Senate re: Fast Completion of pbter - NOW: Personal assistance: Being able to take r L & auml; en & auml; rt: Krnikr, hemvndare and Blog New: doctor closed his eyes for sliver of Gath - Blog New: Sexdmd doctor loses his February (11) January (52)


Wednesday, April 15, 2015

The man entered Sweden October 19, 2007 and applied for residence and work permits October 22 the s


The man entered Sweden October 19, 2007 and applied for residence and work permits October 22 the same year. Through his public defender, chavez cancer he applied April 4, 2008 declaration of refugee status and travel documents.
Ihab Abbood Gatea, as he himself Iraqi citizen, born in 1974, the Migration Board told a story according to which he was subjected to death threats and kidnapping because of his employment at the University Al Naharain. Ihab also claims that his blood disease chavez cancer should give him PUT. Ihab says he was shot on his way home from work in November 2006, he received a letter with a bullet in September 2007 and that he was kidnapped chavez cancer and detained in a Day September 30, 2007. The kidnappers must have released him after his father paid ransom.
Migration Board does not believe that the man proves his identity by the documents he submitted. Migration Board finds, however, that by these documents and their own data has likely you are resident in Iraq.
- The man says that he is a Shia Muslim from Baghdad but was born in Basra. He suffers from a serious blood disease and needs regular maintenance to be given blood transfusions. In February 2008, operated his spleen removed. Since then, his health improved and now you only need to get blood every two weeks, before surgery did you get blood every week. In Baghdad, he received blood when blood values were very low.
- In the Migration Court, he says he health has not improved after his spleen surgically removed. Of the medical documentation shows that he has a serious illness and that he is in need of regular life-sustaining care. The care he received in Iraq had such deficiencies that led to the deterioration. Nowadays, his transfusions preceded by a control and customization of antibodies which health care in Iraq does not have the resources. Healthcare in Iraq in the absence of resources that in a good way to take care of the disease he suffers from.
Migration Board's decision Migration Board did not consider the Ihab had strengthened its identity. The Migration Board also felt that the events Ihab told me about, even if they are true, are sufficient to give Ihad PUT in Sweden as a refugee or subsidiary protection. The fact that Ihab suffering from blood disease thalassemia and need blood transfusions every two weeks considers the Migration Board does not provide a basis for granting Ihab PUT on particularly distressing circumstances where Ihab long ago, these blood transfusions in Iraq. The Swedish Migration Board decided on deportation 19 January 2009.
Migration Court finds that Ihab will need blood transfusions every two weeks for life and that his condition will not be improved by the care available in Sweden. Migration Court notes, however, that Ihab received consequence disease "secondary hemolysis." Resulting disease should he have been due to healthcare in Iraq is too poor to test blood for the special antibodies that cause secondary hemolysis. Migration Court notes from a medical chavez cancer report that:
Migration Court in Stockholm granted March 8, 2010 Ihab PUT because healthcare in Iraq given him sequelae and that he would risk a significantly shortened life if he was forced to return to Iraq. Migration Court in Stockholm - UM 10432-10 as a pdf file.
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I also admire people who can take on a child with special needs, very highly of them ... Hope all i


Coping and dare to adopt a child with special needs, ketogenic diet I think is great. I admire those who do it. The girl Katherine Heigl adopted not long ago has a heart condition. The queues for adopting children with special ketogenic diet needs in Adoption Center is shorter. We are still too young to adopt children with special needs. The needs may include: cleft lip jaw and palate heart defects orthopedic problems, ketogenic diet cerebral palsy hepatitis B + thalassemia epilepsy imperforate anus malformed genitalia hypospadias spina bifida visual and hearing impairments healthy, older children, ie children 6 years and older "mentally retarded"
It is well short queues if you can take care of children with special needs. We have thought about it, mostly because we like to adopt from China and then you have to wait over 4 years. But it feels difficult and I do not know if we're ready. It may be relatively mild stuff, I understand that visual ketogenic diet impairments, for example, can be myopia, and that's myself :) May 21, 2010 21:41
I also admire people who can take on a child with special needs, very highly of them ... Hope all is well, nice that summer is on G! Good luck with everything .. Regards Louise May 21, 2010 22:51
Here you have us; Tea, the man and the miracle. After years of longing, negative pregnancy test, hormones, miscarriage, adoption thoughts, syringes and frustration, she came to us, almost exactly four years after that we decided to be more. My heart is with everyone who is still struggling to become parents. Do not give up, takes over!
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Tuesday, April 14, 2015

Last Inlggen Something that is so damn annoying! Anemia bit Featured Home First World problem Thriv


Barely flu symptoms underneath.

Got some blood on SOS has about a week. Apparently something called Thalassemia, and is hereditary. It is a disease that type makes my blood does not absorb as much oxygen as in others, which means that I get easily flu symptoms tired, weak and decrepit. Not dangerous for turbines me or the baby, but can be a pain to have when you're pregnant, you need all the strength you can get then. ^^ Will get blood again in a few weeks, then you will not need more. :)


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April 9, 2015 Something that is so damn annoying!
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Monday, April 13, 2015

Moreover, an evolutionary require mutations coordinated to fill a beneficial function. However, one


Evolution Proponents believe that life on Earth evolved through random beneficial mutations in very small steps slowly chavez cancer changed the species to what they are today. Such a scenario can not be the subject of scientific experiments - in addition the mutations are too rare and individual life too short. But through chavez cancer the study of organisms with extremely short generation times, such as the malaria parasite, the HIV virus and gut bacterium E. Coli has been possible to follow the effect of prolonged mutation development. The researchers' chavez cancer historical experience of 10,000 years, with the malaria parasite, 50 years with HIV and 10 years of cultivation of intestinal bacteria E. Coli is the amount of mutations that man undergoes 35 million this year, 2.5 billion years and 5.3 million years. And what has come out of this huge amount mutations? Very little. Almost nothing at all.
Moreover, an evolutionary require mutations coordinated to fill a beneficial function. However, one can show that it is unlikely more than 3-4 concerted mutations in the earth's entire existence, 4.5 billion years, which are in evidence in this article. The number chavez cancer of mutations is thus a sort of quantitative limit to what the random mutations can achieve chavez cancer and explains why microevolution (minor changes in species composition) is possible but not macroevolution (transition from one class to another class).
The article also details the malaria parasite's effect on man for perhaps 10,000 years. Humans have this meeting sargats difficult and developed a number of diseases, all of which are deteriorating relative to healthy individuals. In no case is this struggle has given some improvements, such as the theory of evolution advocates.
According to the Darwinian theory of evolution chavez cancer is nature's more than a million different species evolved from a common ancestor through so-called natural selection, where the strongest or best adapted species survive while the weak and ill-suited goes over the competition. Here one must already interpose that this theory from the beginning had and still today has a purely speculative nature. It is based not on facts but on speculation. Darwin eg difficulty of presenting scientific evidence for his theory. The species påståddes have gone under in the competition, the so-called extinct fossil intermediate forms, he had not rediscovered and could therefore also be present. He could not point to any hereditary mechanism that could explain how the 'best' species had their heritable changes. Broadly speaking, the theory of a 'nollsumme' games with a constant heredity pool. It could explain why eg the larger the individual in a family could have greater chance chavez cancer to survive against the smaller but not why a class could be converted to another, e.g. how a reptile could be converted to a bird. This lack of scientific evidence and possible mechanism of action did not prevent the theory from the beginning was given a very enthusiastic response and, as it subsequently turns out, actually went victorious. This must probably be explained by mainly for social reasons. Socialists and Liberals, who were against religion's influence on people's thinking, immediately became strong supporters chavez cancer of the theory. chavez cancer Since Darwin's theory claimed to explain the origins of life and the development of mechanisms chavez cancer that were entirely independent of Creation God so fit this theory, their ideas like a glove. The theory was unfortunately later also be used in racist and colonialist aims.
Today, 150 years after the theory of creation, has the fossil known as intermediate forms have not yet been demonstrated. It would take 70 years before a possible inheritance mechanism, random mutations in the genetic material, could be identified. Only in 1930 was thus the foundation for the development theory, nydarwinismen, which is prevalent today. This neo-Darwinian theory is a synthesis chavez cancer of Darwin's philosophical theory and genetic science and is therefore sometimes also for the synthetic theory. Ironically performed throughout the scientific genetic pioneering work of a Christian monk, Gregor Mendel.
Now if the theory lacked scientific evidence in the form of fossil intermediate forms and possible chavez cancer mechanism of action, chavez cancer so one wonders what it relied on. What Darwin actually claimed as evidence for the theory's accuracy was anatomical similarities between different species and even classes of animals. And it is clear that this is specious. But the similarities between species does not mean automatically that these evolved through random mutations and natural selection, and does not exclude a Creator. In recent years, it mainly in the US but also in other parts of the world emerged a counter-movement among some scientists, who instead declare the species design with an "intelligent designer".
There are many attempts by the mainstream scientific establishment and the media to förlöj

The authors wish to supplement his remarks article Hemolytic colic anemia caused by glucose-6-phos


The authors wish to supplement his remarks article Hemolytic colic anemia caused by glucose-6-phosphate colic dehydrogenase. State with diagnostic pitfalls "of Daniel Eriksson Hogling and Christian Kid (Läkartidningen 48/2013).
The described patient case illustrates the importance of increased awareness of the diagnosis colic of G6PD deficiency and that the sampling is done before blood transfusion. It writes Soheir Beshara and co-author, who with his intervention would complement a previous article in Läkartidningen.
In the article by Daniel Eriksson Hogling and Christian Kid [1] presented a classic case of G6PD deficiency, where the diagnostics according to the authors have been hampered, among other things because of the active hemolysis. Repeated measurements of enzyme activities were considered to be of value in normal initial examination and persistent clinical suspicion. The authors also suggest molecular diagnostic methods useful for screening in populations and families colic or in prenatal diagnostics, where the identification of specific mutations may be useful for better identification of clinical phenotype and provide epidemiological information.
Patient case highlights a classic symptom picture. It is important to note that G6PD deficiency may occur as födoämnesinducerad (favism), infection-induced or drug-induced acute hemolytic anemia. It can also occur as prolonged neonatal jaundice, colic or, very rarely, as a chronic congenital hemolytic anemia [2].
The case illustrates the diagnosis of the disease can be improved with increased awareness of the condition, and that adults may be unaware of their disease and suffer relapses. Increased knowledge of the diagnosis is also important given that immigration to Sweden from countries with a prevalence of G6PD deficiency of 3 percent or higher in the male population increased in recent years. In 2000 was part of Sweden's population of 310 000 individuals from these countries, equivalent to 3.5 percent of the total population; In 2010, the number increased colic to 510,000 (5.5 percent).
The enzyme deficiency is a hereditary colic X-linked genetic defect which point mutations in the G6PD gene results of G6PD variants with different degrees of activity and function occurs. Over 180 different mutations have been described, many of which lacks functional significance [3]. Severe clinical symptoms occur in enzyme activity lower than 10 percent, while variants with 10-60 percent residual enzyme activity may occur with milder symptoms. It is therefore considered quantitative method for measuring enzyme activity, based on the spectrophotometric measurement of NADPH production of NADP, as the standard should be achieved [4, 5]. Limitations in the diagnosis of heterozygous women have been described by mainly using semi-quantitative methods [6]. Molecular diagnostics for population studies are useful only for a homogeneous ethnicity. That is not the case in Sweden, which has immigration from many countries and thus a heterogeneous population in which different mutations of G6PD deficiency may occur.
As with other congenital erytrocytsjukdomar, such as thalassemia, sickle cell anemia and spherocytosis, the blood sampling before a cornerstone for the proper assessment of the analytical results. Information on any given transfusion must be entered in the analysis. It is therefore necessary to test for the diagnosis immediately when the patient is seeking, before blood transfusion is given. If you suspect a false negative test, the test is taken not earlier than two weeks after a relapse, or two months after a transfusion [2].
Reticulocytes contain higher enzyme content than mature erythrocytes, which is believed to contribute to false-normal results. Experience of over a thousand enzyme determinations carried out at the Department of Clinical Chemistry, Karolinska University Laboratory, during the past seven years, however, shows that patients with enzyme colic levels may be associated with a clinical picture has been diagnosed even at very high reticulocyte count. colic
In light of the high prevalence in certain populations, it happens that women are homozygous for the mutation. A number of female patients with such a low enzyme activity has also been identified as heterozygous carriers with only mild impairment of enzyme activity.
The quantitative method shows very good results in the external quality assurance system (UK NEQAS). Diagnosis of mild heterozygosity can be a challenge colic with the quantitative method, but on the other hand, the clinical picture is almost not noticeable. Blood transfusion and lack of information on blood transfusion, colic by contrast, has been the largest colic source of error for falsely normal test results.
Another important, not as well known pitfall is that G6PD deficiency diagnosis can be made more difficult colic by the simultaneous presence of beta-thalassemia, a not uncommon combination colic of these geographic areas. The diagnosis can be made more difficult colic by concomitant iron deficiency [3]. The reference values for neonates is about 50 percent higher than in adults [4], which should be considered in assessing the results of analyzes. A Chart

Sunday, April 12, 2015

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Got up this morning and saw that the ground was dressed in white today! swollen ankles The snow has decided to come out, hahaha .. D: The thing is, the snow is really nice, but is it me, so it is less appreciated. Why you ask? I have two different uh .. blodsjukdommar? Thalassaemia and Raynaud's phenomenon. Now you may be wondering what this is, and I can explain it a little short. Thalassaemia means that my red blood cells suffer too much hemoglobin. This disease is also known for Sickle cell anemia, which in partnership that my blood cells look like half-moons. swollen ankles Or that's what I understand from doctors even ba bblande, haha. However, I ALFA speech Assem in and not the beta. Had I had the beta I would have needed swollen ankles blood transfusions, I'm glad I do not have that. Raynaunds phenomenon, also called "white finger" is a less dangerous "disease", but painful. What happens is that I get to decreased blood flow and cramps in my vessels that go to my toe ro ch fingers. For instance, I do not have rings in the winter swollen ankles because then I run the risk of having to amputate a finger o r two.
Enough swollen ankles about ill d Ommar ... and back to the snow! This is the first time Nemo will experience snow, he's uh .. -räknar on fingrarna- 7 months old! The first thing I did when I went out with him was to carry him, find the biggest snow mountain and throw him into it, he was floundering around like a fish on land, ha ha. He was really shocked by all the snow and playing around two hours, soulma lv I froze and went into quite so directly.
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Saturday, April 11, 2015

Cystic fibrosis is a known example - a broken jontransportprotein provide all possible nasty effect

If gene therapy to insert a gene and straight Big another helicobacter | There is grandeur in this view of life
Most "genes for disease" is, as we have seen, genetic markers where a variation is statistically associated with a gene that affects the risk of a disease in some mostly unknown, rarely entirely clear, manner. But there are a few, very rare, heritable genetic diseases in which a defective variant of a gene causing concern.
Cystic fibrosis is a known example - a broken jontransportprotein provide all possible nasty effects. Huntington's disease, in which a defective variant of the protein huntingtin accumulates in neurons, is another. When the genetic basis of such a disease is described, it is unfortunately still not always clear what to do with the knowledge. Sometimes it gives the genetic basis a better picture of what the disease is doing - but often the opposite is true, that the disease is better known than the gene, and therefore it is the disease that contributes with information about how the gene works. If the missing protein is normally secreted into the blood, it is possible that with hemophilia or diabetes, to manufacture it and give as a replacement.
But the gene itself can not do anything about, except with gene therapy. Gene therapy is just what it sounds like: trying to cure genetic diseases by giving the patient new genetic material - in the simplest case to carry the gene for the protein that is broken. It's an exciting idea that has been an issue since the seventies. There have been many advances since then, but it is still difficult; it will not be a routine procedure within five years, if we say so.
It is relatively easy to insert genes in bacteria or cells in cell culture. The bacteria has already a system of additional DNA rings, called plasmids, which they carry on, spread to their offspring at the pitch and sometimes even handing out copies to other bacteria. And cells in cell culture can be tricked to temporarily take up DNA molecules by shocking them with an electric field (it is called with a vivid expression electroporation).
But that's not good enough if we want to give a person new genes. Human cells have no system for managing helicobacter and although it is possible to get naked DNA in the body - for example, by shooting (!) Into very small metal balls with DNA on the surface - it will not remain for long. No, for inserting a gene into a human and have it remain there, there is really only one way: we need the help of a virus.
Some types of the virus reproduces itself by inserting copies (called proviruses) of their genetic material into the host cell genome. The most famous is probably retroviruses, where the human immunodeficiency virus HIV is included. (That's why retroviruses requires reverse transcriptase to translate their genome into a sequence that can be inserted into the host cell chromosome and then be expressed as if it were one of the host cell's own genes.)
If we remove all the genes that are not required to infect, copy the genome and insert a provirus, we instead place with the gene we want to bring. The modified viral genome is packaged into a viral particle composed helicobacter of proteins that there would no longer have the recipe. This sterile virus called a vector, helicobacter thus a carrier of genetic material.
This example is of the beta-thalassemia, which provides a form of anemia. The problem here is a lack of beta globin, one of the protein chains that make up hemoglobin, the protein that carries oxygen helicobacter in the blood.
On the one hand, it is a great success, how a patient with beta-thalassemia helicobacter (as in the article called P2) after gene therapy began producing beta globin and could end up with blood transfusions. On the other hand, illustrates the perhaps the biggest difficulty with gene therapy (and why gene regulation is not only a concern for geeks, but actually useful knowledge).
Their vector made up of the beta globin - and a few regulatory sequences. helicobacter It is not enough with a coding DNA sequence to get a working gene; the gene must be expressed in the right place, at the right cell type, too. Before each gene before the coding portion starts, is a region with different regulatory DNA sequences, known as promoter. The promoter is different recognition sequences for DNA-binding proteins, which affects how much gene amortized.
The combination of the regulatory sequences contained in the promoter and the transcription factors that are expressed in the cell determines how much a gene to be expressed. (... Almost. It would not biology if there were more levels than that. We will come to an example shortly!) The beauty of beta globin is that the regulatory sequence is relatively specific, so the expression is limited helicobacter to blood cells.
In addition to the promoter, which is just before the gene, there may be other regions with similar functions helicobacter that are not in the beginning of the gene. They are called