Source: www.salute24.ilsole24ore.com has a protective mechanism on brain activity. Stop addiction t

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Source: www.salute24.ilsole24ore.com has a protective mechanism on brain activity. Stop addiction to marijuana thanks to a hormone naturally produced by the body. Researchers at INSERM in Bordeaux led by Pier Vincenzo Piazza and Giovanni Marsicano identified hernias in the action of a molecule produced by the brain, a steroid, pregnenolone, now a potential candidate to break the addiction to TCH, the psychoactive substance in cannabis. The researchers, whose study appears in the first issue of the year in Science, have indeed discovered the role of the molecule in preventing the activation of CB1 receptor of THC that is inserted into the circuit reward-gratification, the same that boosts the consumption cannabis hernias and can lead to the adverse effects of the abuse of the substance, ie cognitive impairment, loss of motivation, modification of the external perceptions and pleasure, memory reduction. How does it work pregnenolone? Until now pregnenolone was considered a prohormone, a precursor to other hormones very important, such as the sex hormones progesterone and testosterone. Scientists have discovered that its function is not "limited" to the synthesis hernias of other molecules, but in a direct manner prevents overstimulation of THC directly to cannabinoid hernias receptors in the brain by binding to them with an antagonistic action. During the studies on mice, it was found that the administration of THC also increases of 3000% within 2 hours of production pregenenolone, naturally produced by the brain to defend its functions that the substance is likely to alter. This mechanism opens the door to new therapeutic approaches for the treatment of addiction to cannibinoidi. But pregnenolone can not be used as a direct treatment, Pier Vincenzo Piazza says, "because it is poorly absorbed when administered orally and once in the blood is rapidly transformed into other steroids." But the researchers did not stop and have developed derivatives of pregnenolone that are stable and active, with "the characteristics of compounds that can be used as a new class of therapeutic drugs," said Piazza still announcing clinical trials to test the potential of the medication. Cosimo Colasanto (01/07/2014) It may also interest you => Politics Pro Marijuana In South America
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