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Written by: Prof. Dr. sc. med. Bozidar thalassemia M. Bojovic Uncontrolled or poorly controlled thalassemia diabetes, in which the course of many years maintained a high glycemic value with frequent ketoacidosis, leading to the emergence of a number of very serious disorders.
Uncontrolled thalassemia or poorly controlled diabetes, in which the course of many years maintained a high glycemic value with frequent ketoacidosis, leading to the emergence of a number of very serious disorders, of which the most important are:
Unfortunately, many young people with diabetes, while still full of energy and life, thinking that these complications and can not or will not happen. It is often a self-delusion that it becomes a reality show all her weight. Clearly then, much less can be done, but to begin on time really thinking about what is inevitable. If you do not have good control of the disease, if high blood glucose values are held for a longer period, if often severe disorders such as ketoacidosis, since problems can not be ignored! They come very quickly and, usually, unfortunately, rarely individually.
There are very real evidence that these problems can be prevented or postponed to the later years of life, if you have a good control of diabetes, if patients behave responsibly adhering to the central principles of nutrition, insulin therapy, physical activity and self-control. There is hope, it is quite realistic if patients gain control diabetes, not she him. To understand the essence of the problem of chronic complications, try to simply view changes in the tiny blood vessels (microangiopathy) and a large fine blood vessels (macroangiopathy). These changes are behind all the complications that can occur after a longer duration of diabetes. DAMAGE OF SMALL VESSEL
When a long time held a highly-glycemia values will cause damage to the small blood vessels. As a result of damage to the small blood vessels thalassemia of the eyes, heart and kidneys, there is a serious disease of these organs, characteristic thalassemia of diabetes. Due to damage to the small blood vessels of the skin and feet, as well as the nervous system, I'll let the problems in them.
High blood glucose levels lead to changes in the form of erythrocytes (red blood cells), which become thickened and stiff, lose elasticity and can not be tightened and tears when passing through small blood vessels. When hardened red blood cells are trying to pass through small blood vessel, she even more damage. Blood vessel becomes weak and porous (permeable). Glucose, also causing damage to the walls of small blood vessels. DAMAGE large arteries thalassemia
High blood glucose values that are held for a longer period, leading to damage and major blood vessels. thalassemia As a consequence of this can lead to high blood pressure, hardening of the arterial blood vessels, heart attack and stroke, poor circulation in the legs and arms.
Red blood cells, hard because of high concentrations of glucose, when passing through the blood vessels damage the inside of their wall leading to scarring in these places. As well as larger blood vessels become stiff and tight. Fatty cholesterol particles collect in places created scars, creating layers that are initially predominantly thalassemia longitudinal, easily raised yellowish stripes on the inner surface of blood vessels. They are composed of accumulated fatty substances therefore, called bold stripes. Time to develop these places so called. fibrous panels, or atheroma plaques consisting of shells composed thalassemia of connective tissue, in whose interior are accumulated thalassemia fatty substances and other products arising from the decomposition of such a plaque. Fibrous plaques have the appearance of solid deposits that bulging in the lumen of blood vessels and lead to its contraction. At these places vortices in the blood stream thalassemia leading to blood clots. In this way, there is a serious narrowing and blockages in, remains of the vessel, with difficulties thalassemia in flowing blood. Due to the increased resistance of blood when going through thalassemia such a constriction, the heart has to work intensively to the resistance, which leads to increased blood pressure.
Changes in the fundus (retina) in the course of diabetes represent one of the most common complications of this disease. Changes occur in the tiny blood vessels, but also the very fabric of intraocular pressure (retinopathy). The cause of these changes are metabolic disorders that exist in diabetes thalassemia and changes in the tiny blood vessels. One can say that all the changes
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