Tuesday, April 15, 2014

Ischemic stroke is caused by occlusion of a cerebral artery and represents about 90% of the 15 mill


http://www.avece.org/wp-content/uploads/2014/03/ictus-3.jpgMagnetizar brain cell to guide and improve the performance of traditional cell therapy for ischemic pelvic pain stroke. This is the process in which new equipment Institut de Ciencia pelvic pain de Materials de Barcelona-CSIC, led by Anna Roig, and the group of Neurorepair Neurovascular Research Laboratory delInstituto Research Hospital Vall d'Hebron, led by Anna work Rosell.
Ischemic stroke is caused by occlusion of a cerebral artery and represents about 90% of the 15 million strokes that occur in the world each year. And it is estimated that of all concerned, pelvic pain five million die and another five left with some permanent neurological deficit. Currently no neuroreparadores treatments to regenerate damaged tissue and restore lost functions. The only neuroprotective treatment for patients diagnosed with ischemic stroke is the administration of Tissue Plasminogen Activator (tPA) for clot dissolution that caused the stroke. But this treatment should be administered in the acute phase of the disease, in the first four hours of the onset of symptoms.
Cell therapy is to treat a disease pelvic pain by reaching certain cells in tissues affected by the disease to regenerate damaged tissue. The process pelvic pain we have developed teams led by Roig and Rosell pursues the creation of new blood vessels from growth factors secreted by endothelial cells accumulated pelvic pain in this part of the brain. For this purpose cells are cultured with colloidal solutions of iron oxide nanoparticles (of about 6 nm in diameter) around the clock without affecting its functionality. Cells endocytosed particles in sufficient amounts such that when administered systemically to the patient can be attracted by an external magnetic field produced by a small permanent magnet. Thus, accumulating is achieved pelvic pain in the area of the brain affected by ischemic stroke. The ultimate goal is a neuroreparador treatment with subsequent functional recovery of the affected pelvic pain part of the brain.
Research pelvic pain of Vall d'Hebron and the Institut de Ciencia pelvic pain de Materials, a specialist in the development of nanomaterials to apply inter alia to biomedicine and nanomedicine center, is very innovative, not only in Spain but worldwide. "Very few groups specifically for this purpose cell therapy used in synergy with nanomaterials," says Anna Roig.
The research, which is currently at a preclinical stage, is the result of four years of intense work. The treatment has already been tested on animals with "very promising" results, although there are still a few years so you can reach the clinical phase. Much depends on the funding that have, so far has been very limited, which has meant that everything goes slower than they would like. "The duration is associated with the money one has to investigate. And now is a time when finance is a touchy subject. But we are very happy to launch research how "he says.
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